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Int J Prev Med. 2019 ;10:45. Epub 2019 Apr 17. PMID: 31143419
Abstract Title:
Evaluating the Protective Role of Ascorbic Acid in Malathion-induced Testis Tissue Toxicity of Male Rats.
Abstract:
Background: Malathion is one of organophosphate pesticides that is widely used in agriculture and crops to control insects. Malathion affects body organs such as the reproductive system by inhibiting acetylcholinesterase activity and induction of oxidative stress. This study is aimed to investigate the effects of malathion on glutathione (GSH) and malondialdehyde (MDA) level in testis of male rats, as well as to study the protective role of Ascorbic Acid.Methods: In this study, 30 adult male Wistar rats weighing approximately 200-250 g were divided into 5 groups of 6 rats each. These groups include a control group (no intervention), sham (normal saline 0.9%), experimental Group 1 (malathion 50 mg/kg), experimental Group 2 (Malathion 50 mg/kg + Ascorbic Acid 200 mg/kg), and experimental Group 3 (Ascorbic Acid 200 mg/kg). Malathion, solvents, and ascorbic acid were injected intraperitoneally. After 6 weeks, all groups were anesthetized, and the right testis was used to measure levels of MDA and GSH. MDA as a marker of lipid peroxidation and GSH content was used.Results: The results showed that malathion increased MDA level and decreased GSH level compared with the control group (
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